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design of novel proton-pump inhibitors with reduced adverse effects

Xiaoyi Li, Hong Kang, Wensheng Liu, Sarita Singhal, Na Jiao, Yong Wang, Lixin Zhu, Ruixin Zhu

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 277-284 doi: 10.1007/s11684-018-0630-3

Abstract: The development of new proton-pump inhibitors (PPIs) with less adverse effects by lowering the pKa valuesDrug-likeness screening was further conducted to obtain the candidates that significantly reduced the adverseeffects of long-term PPI use.

Keywords： proton-pump inhibitor     adverse effect     pharmacological mechanism     toxicological mechanism     pKa calculation    

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Key technologies of precision demolition blasting of ultra-long urban viaduct in complicated surroundings

Xie Xianqi,Jia Yongsheng,Yao Yingkang,Sun Jinshan,Wu Xinxia,Liu Changbang

Strategic Study of CAE 2014, Volume 16, Issue 11,   Pages 65-71

Abstract: Adverse effects were forecasted and controlled by integrated protective technologies.

Keywords： viaduct     blasting demolition     precision blasting     instability model     initiation network     adverse effects control    

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Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 33-42 doi: 10.1007/s11684-019-0735-3

Abstract: activation of effector T cells, ICIs are remarkably associated with a substantial risk of immune-related adverse

Keywords： cancer     immunotherapy     immune checkpoint inhibitors     immune-related adverse events     review    

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Temperature effects of shape memory alloys (SMAs) in damage control design of steel portal frames

Xiaoqun LUO, Hanbin GE, Tsutomu USAMI

Frontiers of Structural and Civil Engineering 2012, Volume 6, Issue 4,   Pages 348-357 doi: 10.1007/s11709-012-0176-4

Abstract: The objective of the present study is to analytically investigate temperature effects of an axial-typeTemperature effects of SMA dampers on seismic performance upgrading are discussed in three aspects: differentHowever, the rapid loading rate induced heat generation has little adverse effect.

Keywords： damage control design     shape memory alloy     temperature effect    

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The Ejection and Sweep in the Wall Region of a Turbulent Boundary Layer Under Adverse Pressure Gradient

Zhang Qiang,Lu Lipeng

Strategic Study of CAE 2003, Volume 5, Issue 11,   Pages 47-50

Abstract:

The evolution of coherent structures in the wall region of a turbulent boundary layer under adversethat to the shear stress, the contribution of sweep motions is stronger than that of ejections under adversethe transport of shear-stress and kinetic energy of turbulence more strongly than the ejections under adverse

Keywords： coherent structures     turbulent boundary layer     adverse pressure gradients     direct numerical simulation    

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Environmental effects and risk control of antibiotic resistance genes in the organic solid waste aerobic

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 6, doi: 10.1007/s11783-021-1415-5

Abstract:

• ARGs were detected in livestock manure, sludge, food waste and fermentation dregs.

Keywords： Antibiotic resistance genes     Organic solid waste     Aerobic composting     Livestock manure     Sludge    

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Size and shape effects of MnFeO nanoparticles as catalysts for reductive degradation of dye pollutants

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 5,   Pages 108-171 doi: 10.1007/s11783-021-1396-4

Abstract: The size and shape effects of MnFe2O4 nanoparticles demonstrated in this work not

Keywords： Dye degradation     MnFe2O4 nanoparticles     Size and shape-control    

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surgical patients at high risk of OSAS using the Berlin Questionnaire to detect potential high risk of adverse

Fei Liu, Li Liu, Fang Zheng, Xiangdong Tang, Yongxin Bao, Yunxia Zuo

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 189-195 doi: 10.1007/s11684-017-0533-8

Abstract: are at a high risk of OSAS and to determine if the BQ could be used to detect potential high risk of adverseFurthermore, the incidence of adverse respiratory events in the PACU was higher in patients with highAge, high risk for OSAS, and smoking were independent risk factors for the occurrence of adverse respiratory

Keywords： obstructive sleep apnea     Berlin Questionnaire     Chinese surgical patients     adverse respiratory event    

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An analysis of the adverse reactions of five kinds of intrauterine devices

Li Huajie

Strategic Study of CAE 2015, Volume 17, Issue 6,   Pages 28-30

Abstract: device (IUD), Aimu ring (MCU), maternal music MCU375, uterine shaped ring GCU300, TCU220C and genefex of adverseThe adverse reactions of MCU375 were serious, the adverse reactions of GCU300 and MCU were followed,and the adverse reactions of TCU220c and Ji Nihuan were the lightest..

Keywords： IUD     adverse reaction     Jeanne ring    

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High pressure air spray assistant power supply control strategies and their effects on diesel engine

HAN Yongqiang, LIU Zhongchang, WANG Zhongshu, ZHU Ruoqun

Frontiers in Energy 2007, Volume 1, Issue 3,   Pages 295-299 doi: 10.1007/s11708-007-0042-6

Abstract: Effects of HPAS on a DI TCA diesel engine under constant engine speed and increased torque (CSIT) transientoperations were studied by using different control strategies.

Keywords： different     after-cooled     real-time controlling     CSIT     supply    

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Adverse Geology Identification Through Mineral Anomaly Analysis During Tunneling: Methodology and Case Article

Zhenhao Xu, Tengfei Yu, Peng Lin, Shucai Li

Engineering 2023, Volume 27, Issue 8,   Pages 150-160 doi: 10.1016/j.eng.2022.09.013

Abstract: span style="font-size:10.5pt">Accurate and effective identification of adverseCurrent methods of identifying adverse geology depend on the experience of geologists and are prone toHere, we propose a method for adverse geology identification in tunnels based on mineral anomaly analysisThe proposed method provides a timely warning when a tunnel enters areas affected by adverse geologyThis method improves our ability to identify adverse geology, from qualitative to quantitative, and can

Keywords： Mineral anomaly     Adverse geology     Fault     Alteration     Anomaly threshold    

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Estimating the effects of meteorology on PM

Liu YANG, Ye WU, Jerry M. DAVIS, Jiming HAO

Frontiers of Environmental Science & Engineering 2011, Volume 5, Issue 3,   Pages 331-341 doi: 10.1007/s11783-011-0307-5

Abstract: To ensure good air quality for the Games, several temporary emission control measures were implementedregression model based on continuous field monitoring at a roadside site was conducted to evaluate the effectsof meteorology and emission control measures on the reduction of PM during the 2008 Olympic Games.and the control period, July 28th to August 21st.Wind direction was not a significant predictor of PM levels in either the control or the no control

Keywords： meteorology     emission control measures     Beijing Olympic Games     PM2.5     linear statistical models    

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Effects of humic acid on residual Al control in drinking water treatment plants with orthophosphate addition

Wendong WANG, Hua LI, Zhenzhen DING, Xiaochang WANG, Rui LIU

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 4,   Pages 470-476 doi: 10.1007/s11783-012-0422-y

Abstract: This study aimed to investigate the effects of humic acid (HA) on residual Al control in drinking waterThe results showed that adding orthophosphate was an effective method for residual Al control for theTot-Al) residue were 0.08 and 0.086 mg·L , respectively; both were reduced by 46% compared with the controlFor water with a HA concentration above 5 mg·L , orthophosphate was ineffective in the control of residualSimilar to the raw water without HA, the best Al control was obtained with orthophosphate salt added

Keywords： coagulation     drinking water     humic acid     orthophosphate     residual Al    

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Response of organic aerosol characteristics to emission reduction in Yangtze River Delta region

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 9, doi: 10.1007/s11783-023-1714-0

Abstract:

● The emission reduction causes significant change in organic aerosol composition.

Keywords： Emission control     Secondary organic aerosol     Atmospheric oxidizing capacity     Holiday effects     COVID-19    

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Effects of a structurally related substance on the crystallization of paracetamol

Ali SALEEMI, I.I. ONYEMELUKWE, Zoltan NAGY

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1,   Pages 79-87 doi: 10.1007/s11705-013-1308-7

Abstract: A supersaturation control (SSC) approach was implemented for the PCM-IPA system with and without metacetamolin an attempt to control and obtain larger metacetamol-doped paracetamol crystals.

Keywords： acetaminophen     metacetamol     crystallization     metastable zone width     induction time     supersaturation control    

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Title Author Date Type Operation

design of novel proton-pump inhibitors with reduced adverse effects

Xiaoyi Li, Hong Kang, Wensheng Liu, Sarita Singhal, Na Jiao, Yong Wang, Lixin Zhu, Ruixin Zhu

Journal Article

Key technologies of precision demolition blasting of ultra-long urban viaduct in complicated surroundings

Xie Xianqi,Jia Yongsheng,Yao Yingkang,Sun Jinshan,Wu Xinxia,Liu Changbang

Journal Article

Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Journal Article

Temperature effects of shape memory alloys (SMAs) in damage control design of steel portal frames

Xiaoqun LUO, Hanbin GE, Tsutomu USAMI

Journal Article

The Ejection and Sweep in the Wall Region of a Turbulent Boundary Layer Under Adverse Pressure Gradient

Zhang Qiang,Lu Lipeng

Journal Article

Environmental effects and risk control of antibiotic resistance genes in the organic solid waste aerobic

Journal Article

Size and shape effects of MnFeO nanoparticles as catalysts for reductive degradation of dye pollutants

Journal Article

surgical patients at high risk of OSAS using the Berlin Questionnaire to detect potential high risk of adverse

Fei Liu, Li Liu, Fang Zheng, Xiangdong Tang, Yongxin Bao, Yunxia Zuo

Journal Article

An analysis of the adverse reactions of five kinds of intrauterine devices

Li Huajie

Journal Article

High pressure air spray assistant power supply control strategies and their effects on diesel engine

HAN Yongqiang, LIU Zhongchang, WANG Zhongshu, ZHU Ruoqun

Journal Article

Adverse Geology Identification Through Mineral Anomaly Analysis During Tunneling: Methodology and Case

Zhenhao Xu, Tengfei Yu, Peng Lin, Shucai Li

Journal Article

Estimating the effects of meteorology on PM

Liu YANG, Ye WU, Jerry M. DAVIS, Jiming HAO

Journal Article

Effects of humic acid on residual Al control in drinking water treatment plants with orthophosphate addition

Wendong WANG, Hua LI, Zhenzhen DING, Xiaochang WANG, Rui LIU

Journal Article

Response of organic aerosol characteristics to emission reduction in Yangtze River Delta region

Journal Article

Effects of a structurally related substance on the crystallization of paracetamol

Ali SALEEMI, I.I. ONYEMELUKWE, Zoltan NAGY

Journal Article